scientific publications

Selection of some of the scientific publications made with the LabPET scanners over the years.

2020

  • Espagnet, R., Lakhssassi, A., Lecomte, R., & Fontaine, R. (2020). A Thermal Model of the LabPET II ASIC. Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment, 953, 163142. https://doi.org/10.1016/j.nima.2019.163142
  • Gaudin, É., Thibaudeau, C., Arpin, L., Bouziri, H., Fontaine, R., & Lecomte, R. (2020). Dual-Threshold Time-over-Threshold Nonlinearity Correction for PET Detectors. Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment, 971, 164100. https://doi.org/10.1016/j.nima.2020.164100
  • Moghadam, N., Arpin, L., Espagnet, R., Bouchard, J., Viscogliosi, N., Lecomte, R., & Fontaine, R. (2020). Performance investigation of LabPET II detector technology in an MRI-like environment. Physics in medicine and biology, 65(3), 035001. https://doi.org/10.1088/1361-6560/ab57e0
  • Loignon-Houle, F., Toussaint, M., Lee, M. S., Cates, J. W., & Lecomte, R. (2020). Experimental validation of a coincidence time resolution metric including depth-of-interaction bias for TOF-PET. Physics in medicine and biology, 10.1088/1361-6560/aba7d0. Advance online publication. https://doi.org/10.1088/1361-6560/aba7d0
  • Barrière, D. A., Midavaine, É., Doré-Savard, L., Kirby, K., Tremblay, L., Beaudoin, J. F., Beaudet, N., Longpré, J. M., Lecomte, R., Lepage, M., & Sarret, P. (2020). Publisher Correction: Dichotomic effects of clinically used drugs on tumor growth, bone remodeling and pain management. Scientific reports, 10(1), 2979. https://doi.org/10.1038/s41598-020-59781-y
  • Carroll, L., Croteau, E., Kertzscher, G., Sarrhini, O., Turgeon, V., Lecomte, R., & Enger, S. A. (2020). Cross-validation of a non-invasive positron detector to measure the arterial input function for pharmacokinetic modelling in dynamic positron emission tomography. Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 76, 92–99. https://doi.org/10.1016/j.ejmp.2020.06.009
  • Moghadam, N., Bouchard, J., Espagnet, R., Fontaine, R., & Lecomte, R. (2020). MRI-compatibility study of a PET-insert based on a low-profile detection front-end with submillimeter spatial resolution. Medical physics, 10.1002/mp.14254. Advance online publication. https://doi.org/10.1002/mp.14254
  • Paquette, M., Phoenix, S., Lawson, C., Guérin, B., Lecomte, R., Tai, L. H., Turcotte, É. E., & Leyton, J. V. (2020). A preclinical PET dual-tracer imaging protocol for ER and HER2 phenotyping in breast cancer xenografts. EJNMMI research, 10(1), 69. https://doi.org/10.1186/s13550-020-00656-8
  • Paquette, M., Phoenix, S., Lavallée, É., Rousseau, J. A., Guérin, B., Turcotte, É. E., & Lecomte, R. (2020). Cross-Species Physiological Assessment of Brain Estrogen Receptor Expression Using 18F-FES and 18F-4FMFES PET Imaging. Molecular imaging and biology, 22(5), 1403–1413. https://doi.org/10.1007/s11307-020-01520-w

2019

  • Barrière, D. A., Midavaine, É., Doré-Savard, L., Kirby, K., Tremblay, L., Beaudoin, J. F., Beaudet, N., Longpré, J. M., Lecomte, R., Lepage, M., & Sarret, P. (2019). Dichotomic effects of clinically used drugs on tumor growth, bone remodeling and pain management. Scientific reports, 9(1), 20155. https://doi.org/10.1038/s41598-019-56622-5
  • Tippayamontri, T., Guérin, B., Ouellet, R., Sarrhini, O., Rousseau, J., Lecomte, R., Paquette, B., & Sanche, L. (2019). Intratumoral 18F-FLT infusion in metabolic targeted radiotherapy. EJNMMI research, 9(1), 33. https://doi.org/10.1186/s13550-019-0496-7
  • Gaudin, É., Toussaint, M., Thibaudeau, C., Paillé, M., Fontaine, R., & Lecomte, R. (2019). Performance Simulation of an Ultra-High Resolution Brain PET Scanner Using 1.2-mm Pixel Detectors. IEEE transactions on radiation and plasma medical sciences, 3(3), 334–342. https://doi.org/10.1109/TRPMS.2018.2877511
  • Toussaint, M., Loignon-Houle, F., Dussault, J. P., & Lecomte, R. (2019). Analytical model of DOI-induced time bias in ultra-fast scintillation detectors for TOF-PET. Physics in medicine and biology, 64(6), 065009. https://doi.org/10.1088/1361-6560/ab038b
  • Moghadam, N., Espagnet, R., Bouchard, J., Lecomte, R., & Fontaine, R. (2019). Studying the effects of metallic components of PET-insert on PET and MRI performance due to gradient switching. Physics in medicine and biology, 64(7), 075003. https://doi.org/10.1088/1361-6560/ab0291
  • Espagnet, R., Lakhssassi, A., Lecomte, R., & Fontaine, R. (2020). A Thermal Model of the LabPET II ASIC. Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment, 953, 163142. https://doi.org/10.1016/j.nima.2019.163142

2018

  • Gaudin, É., Toussaint, M., Thibaudeau, C., Paillé, M., Fontaine, R., & Lecomte, R. (2019). Performance Simulation of an Ultra-High Resolution Brain PET Scanner Using 1.2-mm Pixel Detectors. IEEE transactions on radiation and plasma medical sciences, 3(3), 334–342. https://doi.org/10.1109/TRPMS.2018.2877511
  • Beaudoin, S., Paquette, M., Fafard-Couture, L., Tremblay, M. A., Lecomte, R., Guérin, B., & Leyton, J. V. (2018). Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting. Journal of visualized experiments : JoVE, (133), 55440. https://doi.org/10.3791/55440
  • Houde, M., Schwertani, A., Touil, H., Desbiens, L., Sarrhini, O., Lecomte, R., Lepage, M., Gagnon, H., Takai, S., Pejler, G., Jacques, D., Gobeil, F., Jr, Day, R., & D’Orléans-Juste, P. (2018). Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction. Frontiers in pharmacology, 9, 868. https://doi.org/10.3389/fphar.2018.00868
  • Labbé, S. M., Caron, A., Festuccia, W. T., Lecomte, R., & Richard, D. (2018). Interscapular brown adipose tissue denervation does not promote the oxidative activity of inguinal white adipose tissue in male mice. American journal of physiology. Endocrinology and metabolism, 315(5), E815–E824. https://doi.org/10.1152/ajpendo.00210.2018
  • Paquette, M., Beaudoin, S., Tremblay, M. A., Jean, S., Lopez, A. F., Lecomte, R., Guérin, B., Bentourkia, M., Sabbagh, R., & Leyton, J. V. (2018). NLS-Cholic Acid Conjugation to IL-5Rα-Specific Antibody Improves Cellular Accumulation and In Vivo Tumor-Targeting Properties in a Bladder Cancer Model. Bioconjugate chemistry, 29(4), 1352–1363. https://doi.org/10.1021/acs.bioconjchem.8b00077
  • Paquette, M., Lavallée, É., Phoenix, S., Ouellet, R., Senta, H., van Lier, J. E., Guérin, B., Lecomte, R., & Turcotte, É. E. (2018). Improved Estrogen Receptor Assessment by PET Using the Novel Radiotracer 18F-4FMFES in Estrogen Receptor-Positive Breast Cancer Patients: An Ongoing Phase II Clinical Trial. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 59(2), 197–203. https://doi.org/10.2967/jnumed.117.194654

2017

  • Loignon-Houle, F., Bergeron, M., Pepin, C. M., Charlebois, S. A., & Lecomte, R. (2017). Simulation of scintillation light output in LYSO scintillators through a full factorial design. Physics in medicine and biology, 62(2), 669–683. https://doi.org/10.1088/1361-6560/62/2/669
  • Arguin, G., Bourzac, J. F., Placet, M., Molle, C. M., Paquette, M., Beaudoin, J. F., Rousseau, J. A., Lecomte, R., Plourde, M., & Gendron, F. P. (2017). The loss of P2X7 receptor expression leads to increase intestinal glucose transit and hepatic steatosis. Scientific reports, 7(1), 12917. https://doi.org/10.1038/s41598-017-13300-8
  • Paquette, M., Vilera-Perez, L. G., Beaudoin, S., Ekindi-Ndongo, N., Boudreaut, P. L., Bonin, M. A., Battista, M. C., Bentourkia, M., Lopez, A. F., Lecomte, R., Marsault, E., Guérin, B., Sabbagh, R., & Leyton, J. V. (2017). Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer. Oncoimmunology, 6(10), e1331195. https://doi.org/10.1080/2162402X.2017.1331195
  • Caron, A., Labbé, S. M., Carter, S., Roy, M. C., Lecomte, R., Ricquier, D., Picard, F., & Richard, D. (2017). Loss of UCP2 impairs cold-induced non-shivering thermogenesis by promoting a shift toward glucose utilization in brown adipose tissue. Biochimie, 134, 118–126. https://doi.org/10.1016/j.biochi.2017.01.006
  • O’Farrell, A. C., Evans, R., Silvola, J. M., Miller, I. S., Conroy, E., Hector, S., Cary, M., Murray, D. W., Jarzabek, M. A., Maratha, A., Alamanou, M., Udupi, G. M., Shiels, L., Pallaud, C., Saraste, A., Liljenbäck, H., Jauhiainen, M., Oikonen, V., Ducret, A., Cutler, P., … Byrne, A. T. (2017). A Novel Positron Emission Tomography (PET) Approach to Monitor Cardiac Metabolic Pathway Remodeling in Response to Sunitinib Malate. PloS one, 12(1), e0169964. https://doi.org/10.1371/journal.pone.0169964
  • Mansour, N., Dumulon-Perreault, V., Ait-Mohand, S., Paquette, M., Lecomte, R., & Guérin, B. (2017). Impact of dianionic and dicationic linkers on tumor uptake and biodistribution of [64Cu]Cu/NOTA peptide-based gastrin-releasing peptide receptors antagonists. Journal of labelled compounds & radiopharmaceuticals, 60(4), 200–212. https://doi.org/10.1002/jlcr.3491
  • Paquette, M., Lavallée, É., Phoenix, S., Ouellet, R., Senta, H., van Lier, J. E., Guérin, B., Lecomte, R., & Turcotte, É. E. (2018). Improved Estrogen Receptor Assessment by PET Using the Novel Radiotracer 18F-4FMFES in Estrogen Receptor-Positive Breast Cancer Patients: An Ongoing Phase II Clinical Trial. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 59(2), 197–203. https://doi.org/10.2967/jnumed.117.194654
  • Selivanova, S. V., Lavallée, É., Senta, H., Caouette, L., McEwan, A., Guérin, B., Lecomte, R., & Turcotte, É. (2017). Clinical Trial with Sodium 99mTc-Pertechnetate Produced by a Medium-Energy Cyclotron: Biodistribution and Safety Assessment in Patients with Abnormal Thyroid Function. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 58(5), 791–798. https://doi.org/10.2967/jnumed.116.178509

2016

  • Svetlana V. Selivanova, Éric Lavallée, Helena Senta, Lyne Caouette, Brigitte Guérin, Alexander J. McEwan, Roger Lecomte, Éric Turcotte. (2016). Clinical trial using sodium pertechnetate [Tc-99m] produced with a medium-energy cyclotron: biodistribution and safety assessment in patients with abnormal thyroid function. Journal of Nuclear Medicine (DOI: 10.2967/jnumed.116.178509), 57.
  • Michel Paquette, Luis-Guillermo Perez-Vilera, Simon Beaudoin, Nadia Ekindi-Ndongo, Pierre-Luc Boudreaut, Marc-Andre Bonin, Marie-Claude Battista, M’hamed Bentourkia, Angel F. Lopez, Roger Lecomte, Eric Marsault, Brigitte Guérin, Robert Sabbagh, Jeffrey V. Leyton. (2016). Identification of IL-5Rα protein expression and internalization, a newinvasive bladder cancer marker, and its validation for antibody-based guidedimaging and therapy. Cancer Research (CAN-16-3216).
  • Nematallah Mansour, Véronique Dumulon-Perreault, Samia Ait-Mohand, Michel Paquette, Roger Lecomte, Brigitte Guérin. (2016). Impact of dianionic and dicationic linkers on tumor uptake and biodistribution of [64Cu]NOTA peptide-based GRPR antagonists. Journal of Labelled Compounds and Radiopharmaceuticals (JLCR-16-0147).
  • Jonathan Charest, Jean-François Beaudoin, Mélanie Bergeron, Jules Cadorette, Louis Arpin, Roger Lecomte, Charles-Antoine Brunet, Réjean Fontaine. (2016). Impacts of intelligent automated quality control on a small animal APD-based digital PET scanner. IEEE Transactions on Nuclear Science (DOI: 10.1109/TNS.2016.2605060),63(5), 2550-2557.
  • Suzanne Gascon, Étienne Croteau, Sébastien Tremblay, Otman Sarrhini, Marie-Odile Benoit-Biancamano, Jennifer M. Renaud, Eric E. Turcotte, Roger Lecomte. (2016). Longitudinal PET imaging of myocardial metabolism and heart function with 11C-acetoacetate and 18F-FDG in a mouse model of doxorubicin-induced cardiotoxicity. Journal of Nuclear Medicine (JNUMED/2016/187617).
  • Alexandre Caron, Sébastien Labbé, Sophie Carter, Marie-Claude Roy, Frédéric Picard, Roger Lecomte, D. Ricquier, Denis Richard. (2016). Loss of UCP2 impairs cold-induced non-shivering thermogenesis bypromoting a shift toward glucose utilization in brown adipose tissue. Biochimie.
  • Sébastien M. Labbé, Alexandre Caron, Kanta Chechi, Mathieu Laplante, Roger Lecomte, Denis Richard. (2016). Metabolic activity of brown, beige and white adipose tissues in responseto chronic adrenergic stimulation in male mice. American Journal ofPhysiology: Endocrinology and Metabolism (DOI: 10.1152/ajpendo.00545.2015),311(1), E260-E268.
  • Martin Houde, Adel Schwertani, Louisane Desbiens, Hanène Touil, Roger Lecomte, Martin Lepage, Hugo Gagnon, Shinji Takai, Gunnar Pejler, Robert Day, Pedro D’Orléans-Juste. (2016). Mouse mast cell protease 4 deletion protects heart function and survival after acute myocardial infarction. Journal of Molecular and Cellular Cardiology.
  • Christophe Noll, Sébastien M. Labbé, Sandra Pinard, Michael Shum, Lyne Bilodeau, Lucie Chouinard, Serge Phoenix, Roger Lecomte, André C. Carpentier, Nicole Gallo-Payet. (2016). Postprandial fatty acid uptake and adipocytes remodeling in angiotensin type 2 receptor-deficient mice fed a high-fat/high-fructose diet. Adipocyte (DOI: 10.1080/21623945.2015.1115582),5(1), 43-52.
  • Laurence Convert, Réjean Lebel, Suzanne Gascon, Réjean Fontaine, Jean-François Pratte, Paul Charette, Vincent Aimez, Roger Lecomte. (2016). Real time microfluidic blood counting system for PET and SPECT preclinical pharmacokinetic studies. Journal of Nuclear Medicine (DOI: 10.2967/jnumed.115.162768),57(9), 1460-1466.
  • Francis Loignon-Houle, Catherine M. Pepin, Serge A. Charlebois, Roger Lecomte. (2016). Reflectivity quenching of ESR multilayer polymer film reflector in optically bonded scintillator arrays. Nuclear Instruments and Methods in Physics Research A (NIMA-D-16-01080).
  • Maxime Toussaint, Jean-Pierre Dussault, Roger Lecomte. (2016). Revisiting motion compensation models in PET image reconstruction. Proceedings of the IEEE 13th International Symposium on Biomedical Imaging (ISBI) (DOI: 10.1109/ISBI.2016.7493218),90-94.
  • Francis Loignon-Houle, Catherine M. Pepin, Roger Lecomte. (2016). Scintillation and spectroscopic characteristics of 90%Lu LGSO with variable decay times. IEEE Transactions on Nuclear Science (DOI: 10.1109/TNS.2016.2619179).
  • Francis Loignon-Houle, Mélanie Bergeron, Catherine M. Pepin, Serge A. Charlebois, Roger Lecomte. (2016). Simulation of scintillation light output in LYSO scintillators through a full factorial design. Physics in Medicine and Biology (PMB-104272.R1).
  • Francis Loignon-Houle, Mélanie Bergeron, Catherine M. Pepin, Serge A. Charlebois, Roger Lecomte. (2016). Simulation of scintillation light output in LYSO scintillators through a full factorial design. Physics in Medicine and Biology (PMB-104272).
  • Sébastien Labbe, Mathilde Mouchiroud, Alexandre Caron, Blandine Secco, Elizaveta Freinkman, Patricia Chimin, Yves Gélinas, Guillaume Lamoureux, Roger Lecomte, Yohan Bossé,William Festuccia, Denis Richard, Mathieu Laplante. (2016). mTORC1 is required for brown adipose tissue recruitment and metabolic adaptation to cold. Scientific Reports (DOI:10.1038/srep37223),6(37223), 1-17.

2015

  • Paté Boubacar, Otman Sarrhini, Roger Lecomte, Johan van Lier, M’hamed Bentourkia. (2015). A real-time follow-up of photodynamic therapy during PET imaging. Photodiagnosis and Photodynamic Therapy (DOI: 10.1016/j.pdpdt.2015.05.006),12(3), 428-435.
  • Jonathan Charest, Jean-François Beaudoin, Jules Cadorette, Roger Lecomte, Charles-Antoine Brunet, Réjean Fontaine. (2015). Automatic channel fault detection and diagnosis system for a small animal APD-based digital PET scanner. IEEE Transactions on Nuclear Science (DOI: 10.1109/TNS.2015.2425794),62(3), 1070-1076.
  • Alice C. O’Farrell, Rhys Evans, Johanna M.U. Silvola, Ian S. Miller, Emer Conroy, Suzanne Hector, Maurice Cary, David Murray, Monika A Jarzabek, Ashwini Maratha, Marina Alamanou, Girish Mallya Udupi, Liam Shiels, Celine Pallaud, Antti Saraste, Heidi Liljenbäck, Matti Jauhiainen, Vesa Oikonen, Axel Ducret, Paul Cutler, Fionnuala Mc Auliffe, Jacques A. Rousseau, Roger Lecomte, Suzanne Gascon, Bonnie Ky, Tom L. Force, Juhani Knuuti, William Gallagher, Anne Roivainen, Annette T. Byrne. (2015). Cardiac Metabolic Pathway Remodeling in Response to Sunitinib Malate. Circulation Research (CIRCRES/2015/307631), 0-0.
  • Sébastien M. Labbé, Alexandre Caron, Inan Bakan, Mathieu Laplante, André C. Carpentier, Roger Lecomte, Denis Richard. (2015). In vivo measurement of energy substrate contribution to cold-induced brown adipose tissue thermogenesis. FASEB Journal (DOI: 10.1096/fj.14-266247),29(5), 2046-2058.
  • Mélanie Bergeron, Christian Thibaudeau, Jules Cadorette, Marc-André Tétrault, Catherine M. Pepin, Julien Clerk-Lamalice, Murray Davies, Henri Dautet, Pierre Deschamps, Réjean Fontaine, Roger Lecomte. (2015). LabPET II, an APD-based PET detector module with counting CT imaging capability. IEEE Transactions on Nuclear Science (DOI: 10.1109/TNS.2015.2420796),62(3), 756-765.
  • Myriam Laprise-Pelletier, Meryem Bouchoucha, Jean Lagueux, Pascale Chevallier, Roger Lecomte, Yves Gossuin, Freddy Kleitz, Marc-André Fortin. (2015). Metal chelate grafting at the surface of mesoporous silica nanoparticles (MSNs): physico-chemical and biomedical imaging assessment. Journal of Materials Chemistry B (DOI: 10.1039/c4tb01423e),3(5), 748-758.
  • Rutao Yao, Xiao Deng, Qingyang Wei, Tiantian Dai, Tianyu Ma, Roger Lecomte. (2015). Multipinhole SPECT helical scan parameters and imaging volume. Medical Physics (DOI: 10.1118/1.4933421),42(11), 6599-6609.
  • Éric Poulin, Réjean Lebel, Étienne Croteau, Marie Blanchette, Luc Tremblay, Roger Lecomte, M’hamed Bentourkia, Martin Lepage. (2015). Optimization of the reference region method for dual pharmacokinetic modeling using Gd-DTPA/MRI and ¹⁸F-FDG/PET. Magnetic Resonance in Medicine (doi: 10.1002/mrm.25151),73(2), 740-748.